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世界各地的科学家都为这个项目付出了努力。以下是我们使用的参考文献,想获得更多信息就点开看看吧!

General Structural Biology Information

1. Protein Data Bank (https://www.rcsb.org)

2. Nature Research (https://www.nature.com/subjects/structural-biology)

3. Structural biology shapes up (Link to Science Feature)

Spike Protein

1. Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein (Link to Cell Article)

2. Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV (Link to Nature Article)

3. Site-specific glycan analysis of the SARS-CoV-2 spike (Link to Science Article)

 

ACE2 Receptor

1. Structure of SARS Coronavirus Spike Receptor-Binding Domain Complexed with Receptor (Link to Science Article)

2. Structural basis of receptor recognition by SARS-CoV-2 (Link to Nature Article)

RNA Polymerase

1. Structural and Biochemical Characterization of the nsp12-nsp7-nsp8 Core Polymerase Complex from SARS-CoV-2 (Link to Cell Article)

2. Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase (Link to Cell Article)

3. Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors (Link to Nature Article)

 

Main Protease

1. Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main proteaser (Link to bioRxiv Preprint)

2. Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease (Link to Science Article)

3. Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors (Link to Science Article)

 

Envelope Protein

1. Structural model of the SARS coronavirus E channel in LMPG micelles (Link to BBA Article)

2. Coronavirus envelope protein: current knowledge (Link to Virology Journal Article)

3. The outbreak of SARS-CoV-2 pneumonia calls for viral vaccines (Link to Nature Comment)

 

Public Health

1. Latest Updates on the 2019 Coronavirus Outbreak (Link to Health Canada)

2. Real-time tracking of pathogen evolution (Link to Nexstrain)

3. World Health Organization-COVID-19 Website (Link to the WHO)

 

Kids Page Resources

1. Health Canada Resources for Kids and Parents (Link to Health Canada-Resources)

2. Molecular Landscapes by David S. Goodsell -amazing scientific art (Link to PDB101 Page)

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